I have a fair amount of intermittent stress related to all of the inputs in my life: Twitter, RSS feeds, paper, todos from other people, webpages, e-mails, calls. I have to work on controlling the inputs flow rate as well as effectively be able to process things (ie - GTD). I recently culled several of my inputs.
I love tools that help with fast processing such as NetNewsWire (see ‘L’ key), paper, text files when needed. Some tools are fun to use or exude appeal and design but are not efficient. One example of this is Reeder on the Mac. It looks nice and is fun (in some ways) but is only moderately efficient.
On the other hand, one should not have so much to process that one is forced to only use efficient tools. It is good to have a managable amount of inputs and then use tools that are efficient enough and well-designed as well. NetNewsWire with the Brockman style plus Twitter pulled in via RSS is a nice balance for me.